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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > ATAD3A Antibody (N-term)
ATAD3A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NVI7 |
| Other Accession | Q5T9A4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66218 Da |
| Antigen Region | 24-48 aa |
| Gene ID | 55210 |
|---|---|
| Other Names | ATPase family AAA domain-containing protein 3A, ATAD3A |
| Target/Specificity | This ATAD3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-48 amino acids from the N-terminal region of human ATAD3A. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ATAD3A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATAD3A {ECO:0000303|PubMed:37832546, ECO:0000312|HGNC:HGNC:25567} |
|---|---|
| Function | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane (PubMed:20154147, PubMed:20349121). The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (PubMed:18063578). Also present at mitochondria-endoplasmic reticulum contact sites; where it interacts with EIF2AK3/PERK (PubMed:39116259). |
| Tissue Location | Overexpressed in lung adenocarcinomas (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Ota T., et al. Nat. Genet. 36:40-45(2004).
Gregory S.G., et al. Nature 441:315-321(2006).
Bienvenut W.V., et al. Submitted (JUL-2007) to UniProtKB.
Daub H., et al. Mol. Cell 31:438-448(2008).
Choudhary C., et al. Science 325:834-840(2009).
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$ 385.00
$ 150.00
Cat# AP20535a
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